HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-ethyl-3-methylaniline → N-Ethyl-3-Hydroxy-7-Methyl-1,2,3,4-Tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-ethyl-3-methylaniline | HCID 7603 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Product | N-Ethyl-3-Hydroxy-7-Methyl-1,2,3,4-Tetrahydroquinoline | HCID 20277626 | — |
Reaction Steps
N-ethyl-m-toluidine (1.0 mole) and epichlorohydrin (225 g) were mixed and allowed to stand three days at room temperature. The reaction mixture was heated at 140°-145° C. for 6 hrs. and then distilled under vacuum. The product (100 g) which boiled at 143° C. at 1.1 mmHg was recovered in 52% of the theoretical yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04400318 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-6dd8cc6440c04a388d23121a4c921ddc |
| Source note | uspto-grants-1983_08 |