Ethylene Oxide → HCID 14324235, compound

Participants

Reaction Steps

2,5-Dimethyl-8-methoxy-1,2,3,4-tetrahydroquinoline (189 g, 1.0 m) was reacted with ethylene oxide (52.0 g) in an autoclave at 160° C. for 10 hrs. The reaction mixture from the autoclave was distilled under vacuum to yield 169 g (72%) of product which boiled at 150°-138° C. at 1.7/0.5 mm Hg. A small amount of material was slurried in hexane, and after filtering and drying the product melted at 65°-67° C.

Provenance & Evidence