1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 5-Methylpyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1,4(2H,5H)-dione

HRID 435099Notes

Reaction equation

Cl[C:2]1[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[N:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]=1.[C:14](OC)(=[O:17])[NH:15][NH2:16].C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>>[CH3:9][N:6]1[C:5]2[N:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]2[C:14](=[O:17])[NH:15][N:16]=[C:2]2[C:7]1=[O:8]

Participants

Reactant 3

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)

HCID 80519Methyl carbazate

HCID 134742312-Chloro-4-methylpyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 131929415-Methylpyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1,4(2H,5H)-dione

Conditions

Temperature: 80 °C

Procedure

A mixture of 7.5 g. of 2-chloro-4-methyl-pyrido(2,3-b)pyrazine-3-one, and 4 g. of methyl carbazate in 200 ml. of Dowtherm A was stirred and heated at 80° C. for 1 hour and then at 230° C. for 20 minutes.

Workup

additionA mixture of 7.5 g

Sources & evidence

ORD record: ord-632da28ff2364801a5f56389f3b36cd4
Source dataset: uspto-grants-1983_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04400382

Reaction notes

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