Thionyl Chloride → HCID 13207837, compound

HRID 435103Notes

Reaction equation

HRID 435103 reaction equation
S(Cl)([Cl:3])=O.[ClH:5].Cl.[CH3:7][C@H:8]1[NH:13][C@@H:12]([CH3:14])[CH2:11][N:10]([CH2:15][CH2:16][CH2:17]O)[CH2:9]1>>[ClH:3].[ClH:5].[CH3:7][C@H:8]1[NH:13][C@@H:12]([CH3:14])[CH2:11][N:10]([CH2:15][CH2:16][CH2:17][Cl:5])[CH2:9]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22822903HCID 22822903, compound

Product 1

HCID 13207837HCID 13207837, compound

Procedure

Thionyl chloride (300 g) was slowly added to 3-(3,5-cis-dimethylpiperazino)propanol dihydrochloride (200 g). The reaction was gently refluxed for an hour followed by removal of excess thionyl chloride by vacuum distillation. The resulting solid was washed with several portions of benzene then several portions of ether, m.p. 291°-292°.

Workup

  1. temperatureThe reaction was gently refluxed for an hour
  2. customfollowed by removal of excess thionyl chloride by vacuum distillation
  3. washThe resulting solid was washed with several portions of benzene

Sources & evidence

ORD record
ord-9d56b3cc5e3f4deaaab5922405d5c7d6
Source dataset
uspto-grants-1983_08
Patent number
US04400383

Reaction notes

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