Acetic Acid → HCID 70083960, compound

HRID 435105Notes

Reaction equation

HRID 435105 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][CH2:10][CH2:11][N:12]2[C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:18]3[C:13]2=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:3]1.[C:25]([OH:28])(=[O:27])[CH3:26]>C1(C)C=CC=CC=1>[C:25]([OH:28])(=[O:27])[CH3:26].[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][CH2:10][CH2:11][N:12]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]3[C:24]2=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:3]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53389Rimcazole

Product 1

HCID 70083960HCID 70083960, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To the 9-[3-(3,5-cis-dimethylpiperazino)-propyl]-carbazole (10 g) of Example 4 dissolved in hot toluene (70 ml) was added acetic acid (2.0 ml). The mixture was stirred and cooled to 2°. The resulting product was collected by filtration, washed with cyclohexane (35 ml) and dried under reduced pressure to give cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole acetate one-quarter hydrate (10.4 g), m.p. 144°-146°, which had the following elemental analysis:

Workup

  1. temperaturecooled to 2°
  2. filtrationThe resulting product was collected by filtration
  3. washwashed with cyclohexane (35 ml)
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-f273f07f72464ff9bf7b1fbb75d19cf7
Source dataset
uspto-grants-1983_08
Patent number
US04400383

Reaction notes

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