Sulfuric Acid → HCID 13131688, compound

Participants

Reaction Steps

To the cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole (10 g) of Example 4 dissolved in warm acetone (100 ml) was slowly added with stirring a solution of sulfuric acid (3.05 g) in water (5 ml), causing immediate precipitation. The slurry was stirred at reflux for 10 min. and then cooled to 20°. The product was collected by filtration and washed with acetone (20 ml). It was reslurried in water (70 ml), filtered, washed with acetone (40 ml) and dried under reduced pressured to give cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole sulfate monohydrate (12.9 g), m.p. 243°-246° (dec.), which had the following analysis:

Provenance & Evidence