反应详情

One mole of theophylline is dissolved in 2.5 liters of acetic acid containing one liter of water, and kept at 50° C., until the theophylline is dissolved and the medium becomes homogeneous. 1.1 mole of bromine is then added, drop by drop, and the bromine derivative, 8-bromotheophylline precipitates in the medium. The solution is then ccoled to room temperature , and the product filtered and washed with water, and then dried to give 70-85% yield of 8-bromo-theophylline.

1. dissolutionis dissolved
2. customdrop by drop, and the bromine derivative, 8-bromotheophylline precipitates in the medium
3. customis then ccoled to room temperature
4. filtrationthe product filtered
5. washwashed with water
6. customdried