HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinolin-5-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N-(6-Fluoro-2-methylquinolin-5-yl)acetamide | HCID 12896814 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Product | N-(6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinolin-5-yl)acetamide | HCID 15571780 | — |
Reaction Steps
The nitro group is reduced catalytically, for example, in the presence of palladium on charcoal. If this reaction is carried out in the presence of acetic anhydride, the product is the compound 5-acetamido-6-fluoroquinaldine. This intermediate is further reduced catalytically in the presence of platinum on charcoal to provide the compound 5-acetamido-6-fluorotetrahydroquinaldine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04400386 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-0226b0fe0fa6485ca63ce9bb393a4eb1 |
| Source note | uspto-grants-1983_08 |