Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | HCID 13156221 | HCID 13156221 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | HCID 20490860 | HCID 20490860 | — |
Reaction Steps
A mixture of 5.0 g (16.9 mmole) of ethyl 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylate, 10 g of sodium acetate, 2 g of Raney nickel and 100 ml of acetic anhydride was stirred under hydrogen gas on a Paar apparatus at 50 psi and 50° C. for six hours. The catalyst was removed by filtration, and the filtrate was evaporated. The residue was dissolved in isopropyl alcohol and slowly crystallized to provide white crystals of ethyl 8-acetamidomethyl-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylate. The structural assignment was supported by infrared spectral analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04400386 |
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| Source dataset | uspto-grants-1983_08 |
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| ORD ID | ord-f33bdcd631dc43fd92415c2379036452 |
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| Source note | uspto-grants-1983_08 |
|---|
