2,2,6,6-Tetramethyl-4-piperidone → 5,5,7,7-Tetramethyl-1-oxa-6-azaspiro[2.5]octane

Participants

Reaction Steps

44.55 g (0.825 mole) of CH3ONa were then added, under stirring, to the mixture and then, in half an hour, a solution of 77.5 g (0.5 mole) of triacetonamine dissolved in 50 cc of CH3CN was gradually added. After having stirred the mixture for 4 hours at room temperature, most of the solvent was distilled under vacuum and 500 cc of H2O were added to the mixture.

Provenance & Evidence