反应详情

1.5 g of o-phthalaldehydic acid and 1.5 g of p-aminophenylacetic acid were added to 30 ml of methanol to form a mixture which was agitated at room temperature for one hour and incorporated with 0.54 g of potassium boron hydride in several portions. Then, the whole was reacted at room temperature of 5 hours and then freed from the solvent under a reduced pressure. The resulting residue was incorporated with 50 ml of water and then with a small amount of acetic acid to obtain an acidic solution, after which crystals precipitated from the thus obtained solution were filtered off, dried and recrystallized from ethanol to obtain 2.5 g of 1-oxo-2 -{p-(carboxymethyl)-phenyl}-isoindoline.

1. customto form a mixture which
2. customThen, the whole was reacted at room temperature of 5 hours
3. customafter which crystals precipitated from the thus obtained solution
4. filtrationwere filtered off
5. customdried
6. customrecrystallized from ethanol