反应详情

1.64 g of o-phthalaldehydic acid methyl ester and 1.5 g of p-aminophenylacetic acid were added to 30 ml of methanol to form a mixture which was agitated at room temperature for one hour and incorporated with 0.54 g of potassium boron hydride in several portions. The whole was reacted at room temperature for 15 hours and freed from the solvent by distillation at a reduced pressure to obtain a residue. The thus obtained residue was incorporated with 50 ml of water and then with a small amount of acetic acid to form an acidic solution, after which crystals precipitated from said solution were filtered off, dried and recrystallized from ethanol thereby to obtain 2.4 g of 1-oxo-2-{p-(carboxymethyl)-phenyl}-isoindoline having the following properties:

1. customto form a mixture which
2. customThe whole was reacted at room temperature for 15 hours
3. distillationfreed from the solvent by distillation at a reduced pressure
4. customto obtain a residue
5. customafter which crystals precipitated
6. filtrationwere filtered off
7. customdried
8. customrecrystallized from ethanol