Formic Acid → HCID 178518000、化合物

HRID 435168ノート

反応式

HRID 435168 の反応式
[F:1][C:2]1[N:7]=[C:6]([NH:8][NH:9][C:10]([NH2:12])=[O:11])[CH:5]=[CH:4][CH:3]=1.[CH:13](O)=O>>[F:1][C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[N:12][C:10]([OH:11])=[N:9]2)[CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 1478413[(6-Fluoropyridin-2-yl)amino]urea

生成物 1

HCID 178518000HCID 178518000、化合物収率 60%

実験手順

A solution was prepared by admixing 17 g (0.10 m) of 2-(6-fluoro-2-pyridinyl)hydrazinecarboxamide and 60 mls of 98 percent formic acid. This mixture was stirred and refluxed for 2 hours and allowed to cool to room temperature. The insolubles were filtered off and dried to produce 3.5 g of the desired 1-(6-fluoro-2-pyridinyl)-1H-1,2,4-triazol-3-ol which melted at 290° C. with decomposition. The excess formic acid in the remaining liquid phase was distilled off under reduced pressure and the solids which precipitated were washed and dried. This product was a second crop of the desired product which also melted at 290° C. The product was recovered in a yield of 60 percent of theoretical and upon analysis, was found to have carbon, hydrogen and nitrogen contents of 46.80, 2.89 and 31.17 percent, respectively, as compared with the theoretical contents of 46.47, 2.80 and 31.10 percent, respectively, as calculated for the above named compound.

後処理

  1. customA solution was prepared
  2. temperaturerefluxed for 2 hours
  3. filtrationThe insolubles were filtered off
  4. customdried

出典と根拠

ORDレコード
ord-3a302a45e68c49f4b5c4ffb9f5a03d5e
出典データセット
uspto-grants-1983_08
特許番号
US04400516

反応ノート

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