Benzil-di(beta-bromoethyl)ketal → Benzil-di(beta-succinimidoethyl)ketal

Participants

Reaction Steps

One hundred (100) grams of benzil-di(β-bromoethyl)ketal and 60.5 g of sodium succinimide were dissolved in 500 ml of N,N-dimethylformamide (to be referred to as DMF), and the solution was heated at 50° to 60° C. for 6 hours with stirring. After the reaction, the reaction mixture was poured into 1 liter of ice water. The resulting crystals were filtered, thoroughly washed with water, and dried to afford 95 g (88% yield) of benzil-di(β-succinimidoethyl)ketal as white crystals. Recrystallization from ethanol yielded crystals having a melting point of 90° to 92° C. The product is referred to as initiator 1.

Provenance & Evidence