Ammonia → HCID 10931917, compound

Participants

Reaction Steps

7.7 ml (37 mmoles) of hexamethyldisilazane were added to 5.0 g (49.5 mmoles) of α,α-dimethylpropionamide and 10 mg (0.05 mmole) of saccharin in 15 ml of refluxing tolune over 15 minutes and after refluxing for 45 minutes, the evolution of ammonia had stopped completely. Evaporation and drying in vacuo yielded 8.04 g (98%) of N-trimethylsilyl-α,α-dimethylpropionamide melting at 101°-105.5° C. According to NMR analysis, the purity of the product was 92%.

Provenance & Evidence