HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 2-iso-butoxyimino-4-chloro-3-oxobutyrate | HCID 54168146 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate | HCID 53811669 | 50.8% |
Reaction Steps
Ethyl 2-iso-butoxyimino-4-chloro-3-oxobutyrate (syn isomer, 31.9 g.), thiourea (9.72 g.), sodium acetate 3-hydrate (17.4 g.), ethanol (120 ml.) and water (80 ml.) were treated in a similar manner to that of Example F-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate (syn isomer, 17.6 g.), mp 122° to 124° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04400379 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-b404ac80adf145179aed636707ecf3b3 |
| Source note | uspto-grants-1983_08 |