Formic Acid → 2-(2-Formamidothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Formic Acid	HCID 284	—
Reactant	Acetic Anhydride	HCID 7918	—
Reactant	2-(2-Aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid	HCID 53829489	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-(2-Formamidothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid	HCID 53972144	80.3%

Reaction Steps

2-(2-Aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid (syn isomer, 15 g.), acetic anhydride (24.5 g.), formic acid (11.0 g.) and tetrahydrofuran (50 ml.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid (syn isomer, 13.4 g.), mp 155° C. (dec.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04400379
Source dataset	uspto-grants-1983_08
ORD ID	ord-586830c0504746f984d95eebf366c137
Source note	uspto-grants-1983_08