Water → HCID 54180953, compound

HRID 435387Notes

Reaction equation

HRID 435387 reaction equation
[CH2:1]([O:9][N:10]=[C:11]([C:17](=O)[CH2:18]Cl)[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[NH2:21][C:22]([NH2:24])=[S:23].O.O.O.C([O-])(=O)C.[Na+].O>C(O)C>[NH2:24][C:22]1[S:23][CH:18]=[C:17]([C:11](=[N:10][O:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:21]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2723790ThioureaHCID 23665404Sodium Acetate TrihydrateHCID 54423660HCID 54423660, compound

Product 1

HCID 54180953HCID 54180953, compoundYield 35.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-n-octyloxyimino-4-chloro-3-oxobutyrate (syn isomer, 169.6 g.), thiourea (42.3 g.), sodium acetate trihydrate (75.5 g.), water (420 ml.) and ethanol (1020 ml.) were treated in a similar manner to that of Example F-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-n-octyloxyiminoacetate (syn isomer,65 g.), mp 77° to 78° C.

Sources & evidence

ORD record
ord-c767b66e4b03403eba60fd0c70798ea7
Source dataset
uspto-grants-1983_08
Patent number
US04400379

Reaction notes

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