Hydrochloric Acid → HCID 13091035, compound

Participants

Reaction Steps

The substance [18] (81 g, 135.5 mM) was dissolved in ethanol (300 ml). 1 N NaOH (176.15 ml, 1.3 molar excess) was added dropwise at 0° C. during 30 minutes and the mixture was stirred at room temperature for three hours. The reaction mixture was neutralized by adding 1 N HCl at 0° C. and ethanol was distilled off in vacuo. Water (300 ml) was added to the aqueous layer, which was then washed twice with ether, and 1 N HCl (150 ml) was at 0° C. and the mixture was extracted with ethyl acetate (400 ml). The ethyl acetate layer was washed with water, dried with anhydrous magnesium sulfate and concentrated in vacuo. The thus-obtained oily material was dried in vacuo. The powder was reprecipitated with ether-hexane to obtain the substance [19] (65.0 g, yield: 94.5%).

Provenance & Evidence