Hydrochloric Acid → HCID 178427517, compound

Participants

Reaction Steps

The substance [38] (35.04 g, 50 mM) was dissolved in methanol (200 ml). Ln-HCl (60 ml, 60 mM) was added dropwise during 20 minutes at 0° C. and the mixture was stirred at room temperature for 90 minutes. 1 N HCl (10 ml) was added to the reaction mixture at 0° C., methanol was removed in vacuo, and 1 N HCl (55 ml) was added thereto at 0° C. (pH 2). The precipitate was filtered and dried in vacuo (27.95 g). The filtration was extracted with chloroform. The chloroform layer was washed three times with saturated sodium chloride and water and dehydrated with anhydrous sodium sulfate, then concentrated in vacuo. The residue was combined with the above, and twice recrystallized to obtain the substance [39] (29.22 g, yield: 86.9%).

Provenance & Evidence