Thionyl Chloride → 4-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

HRID 43541Notes

Reaction equation

HRID 43541 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:9]([OH:11])=O)[NH:5][C:6]=1[CH2:7][CH3:8].S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([Cl:14])=[O:11])[NH:5][C:6]=1[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 675489294-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

Product 1

HCID 866485554-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

Conditions

Temperature
75 °C

Procedure

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (55 mg, 0.29 mmol) was dissolved in thionyl chloride (1.5 mL), and the mixture was stirred at 75° C. for 50 minutes. The reaction solution was concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe resulting compound was used for the next reaction without purification

Sources & evidence

ORD record
ord-97e94a26a3554dc48ecdb2e16e7f084b
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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