反应详情

To the solution of 1.5 g of 1-(4-carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester in 13.5 ml of methanol is added 13.5 ml of N aqueous sodium hydroxide and the mixture is stirred at room temperature for 3 hours. It is concentrated at room temperature and reduced pressure, the aqueous solution filtered, cooled and acidified with concentrated hydrochloric acid. The mixture is extracted with methylene chloride, the extract dried, evaporated, the residue recrystallized from petroleum ether and triturated with diethyl ether, to yield the 1-(4-carboxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid melting at 117°-119°.

1. concentrationIt is concentrated at room temperature
2. filtrationreduced pressure, the aqueous solution filtered
3. temperaturecooled
4. extractionThe mixture is extracted with methylene chloride
5. customthe extract dried
6. customevaporated
7. customthe residue recrystallized from petroleum ether
8. customtriturated with diethyl ether