HuagongsheHuagongshe Chemistry Print Report · For research reference only
M-Cresol → alpha-Hydroxy-beta-(3-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | M-Cresol | HCID 342 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide | HCID 13041334 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | alpha-Hydroxy-beta-(3-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide | HCID 13041341 | — |
Reaction Steps
This compound was prepared as in Example 12 from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (6.16 g.), m-cresol (3.3 g.), sodium hydride (50% oil dispersion, 1.5 g.), 18-crown-6 (0.9 g.), and acetonitrile (250 ml.). The product which was recrystallized from ether melted at 158°-159°, and weighed 3.2 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04401832 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-39b893901cd44058ad31cfc6afb24a98 |
| Source note | uspto-grants-1983_08 |