HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → alpha-[(1-Methylethylamino)methyl]-beta-(2-Methylphenoxy)Benzeneethanol, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | alpha-Hydroxy-beta-(2-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide | HCID 13041342 | — |
| Product | alpha-[(1-Methylethylamino)methyl]-beta-(2-Methylphenoxy)Benzeneethanol, Hydrochloride | HCID 13041359 | — |
Reaction Steps
This compound was prepared by reduction of α-hydroxy-N-(1-methylethyl)-β-(2-methylphenoxy)benzenepropanamide (1.8 g.) with borane-tetrahydrofuran complex (1 M solution in tetrahydrofuran, 13 ml.) and subsequent treatment with hydrochloric acid as described in Example 24. The crude product was purified by recrystallization from tetrahydrofuran. The product melted at 193°-195°, and weighed 0.75 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04401832 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-889049da5e004582aa334f4ffc694b3d |
| Source note | uspto-grants-1983_08 |