Methane → HCID 21455932, compound

Participants

Reaction Steps

1.8 g. 3-(5-nitro-1-β-acetoxyethyl-2-imidazolyl)-6-(4-methyl-1 -piperazinyl)-s-triazolo[4,3-b]pyridazine (obtained according to Example 23) was reacted for 1.5 hours at 50° C. with 36 ml. 2N hydrochloric acid. The solution was then treated with charcoal, evaporated in a vacuum and the residue dissolved in 10 ml. water, adjusted to about pH 9 with concentrated aqueous ammonia, left to stand for about 30 minutes and the precipitated crystals were filtered off with suction and washed with water and ether. There was thus obtained 1.1 g. of the desired 3-(5-nitro- 1-β-hydroxyethyl-2-imidazolyl)-6-(4-methyl-1-piperazinyl)-s-triazolo[ 4,3-b]pyridazine. After drying for 1.5 days in a vacuum at 70°C., the product has a melting point of 98° - 100° C. (foams up).

Provenance & Evidence