Isopropanol → 3-(5-Nitro-1-methyl-2-imidazolyl)-6-(4-hydroxy-1-piperidinyl-methyleneamino)-s-triazolo[4,3-b]pyridazine

Participants

Reaction Steps

1.2 g. crude 3-(5-nitro-1-methyl-2-imidazolyl)-6-ethoxymethyleneamino-s-triazolo[ 4,3-b]pyridazine dissolved in 13 ml. of a mixture of isopropanol and dioxan ( 7:3), was mixed, N-methylpyrrolidone while stirring at 20° C., with 4-hydroxypiperidine. After 30 minutes, the precipitated crystals were filtered off with suction, washed with isopropanol and water and dried at 120° C. in a vacuum. There was thus obtained 0.6 g. of the desired 3-(5-nitro-1-methyl- 2-imidazolyl)-6-(4-hydroxy-1-piperidinyl-methyleneamino)-s-triazolo[ 4,3-b]-pyridazine, which has a melting point of 188° - 190° C.

Provenance & Evidence