1,4-Dioxane → HCID 21455987, compound

Participants

Reaction Steps

1.96 g. crude 3-(5-nitro-1-methyl-2-imidazolyl)-6- -chloro-s-triazolo[4,3-b]pyridazine was dissolved in 35 ml. of a mixture of dioxan and methanol (1:1), 0.84 g. sodium methylate added thereto, the reaction mixture heated under reflux for 1 hour, the solution then evaporated in a vacuum, the residue triturated with water, filtered with suction and dried at 120° C. in a vacuum. There was thus obtained 0.64 g. of the desired 3-(5-nitro-1-methyl-2-imidazolyl)-6-methoxy-s-triazolo[4,3-b] pyridazine, which has a melting point of 193° - 198° C.

Provenance & Evidence