Benzene → HCID 12362919, compound

Participants

Reaction Steps

124 g of 10,11-dihydro-2-nitro-dibenzo[b,f]thiepin- 10-ol are suspended in 69.5 ml of pyridine, 615 ml of benzene and 350 ml of chloroform and the mixture is treated dropwise with stirring at 0° C with 53 ml of thionyl chloride. The mixture is stirred overnight at room temperature and then for a further 30 minutes at 35° - 40° C, cooled and diluted with water. The organic phase is washed successively with water and aqueous sodium bicarbonate solution, dried over magnesium sulphate and evaporated. There is obtained 10-chloro-10,11 -dihydro-2-nitro-dibenzo[b,f]thiepin of melting point 74° - 77° C.

Provenance & Evidence