Water → HCID 12232368, compound

Participants

Reaction Steps

A solution of 10.3 g of 10,11-dihydro-2-iodo-dibenzo[b,f]thiepin-10-ol in 64 ml of benzene, 45 ml of chloroform and 6.3 ml of pyridine is treated dropwise at -5° C with 5.7 ml of thionyl chloride. The mixture is stirred for 90 minutes at room temperature and for 30 minutes at 35°-40° C and is subsequently treated with water. The organic phase is washed successively with aqueous sodium bicarbonate solution and water, dried over magnesium sulphate, filtered and concentrated. There is obtained 10-chloro- 10,11-dihydro-2-iodo-dibenzo[b,f]thiepin as a brown oil.

Provenance & Evidence