Piperazine → HCID 21456041, compound

Participants

Reaction Steps

10.1 g of 10-chloro- 10,11-dihydro-2-iodo-dibenzo[b,f]-thiepin and 23.3 g of piperazine are held at 120°-130° C for 1 hour. The mixture is cooled, diluted with 2-N sodium hydroxide and extracted with ether. The organic phase is washed with water until neutral and extracted with 500 ml of 2-N hydrochloric acid. The aqueous phase is made alkaline and extracted with chloroform. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. There is obtained 1-(10,11-dihydro-2-iodo-dibenzo[b,f]thiepin-10-yl)-piperazine as a brown oil.

Provenance & Evidence