反应详情

80 g of 3-fluoro-6-(phenylthio)-phenylacetonitrile, 225 ml of ethanol, 75.5 g of potassium hydroxide and 225 ml of water are heated under reflux for 9 hours. The ethanol is subsequently evaporated off under reflux and the residue treated with water until completely dissolved, whereafter the neutral constituents are extracted with benzene. The aqueous solution is acidified with concentrated hydrochloric acid and extracted with chloroform. The organic phase is washed with water, dried over sodium sulphate and evaporated under reduced pressure. There is obtained 3-fluoro-6-(phenylthio)-phenylacetic acid which melts at 80°-83° C.

1. temperatureunder reflux for 9 hours
2. customThe ethanol is subsequently evaporated off
3. temperatureunder reflux
4. additionthe residue treated with water
5. dissolutionuntil completely dissolved, whereafter the neutral constituents
6. extractionare extracted with benzene
7. extractionextracted with chloroform
8. washThe organic phase is washed with water
9. dry with materialdried over sodium sulphate
10. customevaporated under reduced pressure