Thionyl Chloride → HCID 15619001, compound

HRID 435655Notes

Reaction equation

HRID 435655 reaction equation
[C:1]1([S:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:9]=2[CH2:10]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:22])=O>C1C=CC=CC=1>[C:1]1([S:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:9]=2[CH2:10][Cl:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 122239522-(Phenylthio)-5-(trifluoromethyl)benzenemethanol

Product 1

HCID 15619001HCID 15619001, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

96 g of 2-(phenylthio)-5-trifluoromethyl-benzyl alcohol are dissolved in 450 ml of absolute benzene and heated to reflux. The solution thus obtained is treated dropwise over a period of 20 minutes with 48 ml of thionyl chloride and the mixture is subsequently stirred at reflux for 30 minutes. After cooling, the mixture is evaporated under reduced pressure. There is obtained 2-(phenylthio)-5-trifluoromethyl-benzyl chloride as a brown-yellow oil.

Workup

  1. temperatureheated to reflux
  2. customThe solution thus obtained
  3. temperatureat reflux for 30 minutes
  4. temperatureAfter cooling
  5. customthe mixture is evaporated under reduced pressure

Sources & evidence

ORD record
ord-83f93d80fb584710ad212ad0db9205f3
Source dataset
uspto-grants-1977_02
Patent number
US04006145

Reaction notes

Loading…