反应详情

15 g of 2-phenylthio-5-trifluoromethyl-phenylacetonitrile, 15.1 g of sodium hydroxide, 90 ml of water and 23 ml of ethanol are heated under reflux for 12 hours and subsequently concentrated. After the addition of 200 ml of water, the residue is extracted with 100 ml of benzene. The aqueous phase is back-extracted with 50 ml of benzene. The combined organic phases are extracted with 0.5-N aqueous sodium hydroxide solution. The aqueous phase is acidified with hydrochloric acid and extracted with 150 ml of chloroform. The organic phase is washed with aqueous sodium chloride solution, dried and evaporated. There is obtained 2-(phenylthio)-5-trifluoromethyl-phenylacetic acid in the form of crystals which melt at 102°-103° C.

1. temperatureunder reflux for 12 hours
2. concentrationsubsequently concentrated
3. additionAfter the addition of 200 ml of water
4. extractionthe residue is extracted with 100 ml of benzene
5. extractionThe aqueous phase is back-extracted with 50 ml of benzene
6. extractionThe combined organic phases are extracted with 0.5-N aqueous sodium hydroxide solution
7. extractionextracted with 150 ml of chloroform
8. washThe organic phase is washed with aqueous sodium chloride solution
9. customdried
10. customevaporated