Ammonium formate → Ethyl 2-(4-aminophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

The same operation as in Example (90d) was performed using ethyl 4-methyl-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate obtained in Example (94a) (0.40 g, 1.36 mmol), 10% Pd/C (wet, 1.2 g), ammonium formate (0.52 g, 8.22 mmol) and methanol (10 mL), to obtain 0.27 g of the crude title compound as a light yellow solid (75%).

Provenance & Evidence