Potassium Iodide → HCID 21456035, compound

Participants

Reaction Steps

2.7 g of 1-(10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl)-piperazine are treated, together with 4.3 g of powdered potassium carbonate, 200 mg of potassium iodide and 90 ml of toluene, with 3.2 g of N-(β-chloroethyl)-oxazolidinone and the mixture is heated for 24 hours under reflux. Then the mixture is poured on to ice-water, diluted with benzene and the organic phase washed with saturated soda solution and water, dried over sodium sulphate and concentrated under reduced pressure. There is obtained 3-[2-[4-(10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl]-2-oxazolidinone which is recrystallised from acetone/petroleum ether. The maleate melts at 159°-161° C.

Provenance & Evidence