Ethylene Glycol → HCID 21456039, compound

HRID 435671Notes

Reaction equation

HRID 435671 reaction equation
C([N:6]1[CH2:11][CH2:10][N:9]([CH:12]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[S:16][C:15]3[CH:23]=[CH:24][C:25]([CH3:27])=[CH:26][C:14]=3[CH2:13]2)[CH2:8][CH2:7]1)(OCC)=O.C(O)CO.[OH-].[K+]>O>[CH3:27][C:25]1[CH:24]=[CH:23][C:15]2[S:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH:12]([N:9]3[CH2:8][CH2:7][NH:6][CH2:11][CH2:10]3)[CH2:13][C:14]=2[CH:26]=1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 21456042HCID 21456042, compound

Product 1

HCID 21456039HCID 21456039, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

5.4 g of 1-carbethoxy-4-(10,11-dihydro-2-methyl-dibenzo-[b,f]thiepin-10-yl)-piperazine, 80 ml of ethylene glycol, 4.64 g of potassium hydroxide and 0.33 ml of water and heated for 0.75 hour at 160° C. Then the mixture is poured on to water, extracted with ether, the extracts washed with saturated sodium chloride solution, dried over sodium sulphate and evaporated. There is obtained 1-(10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl)-piperazine as an oil.

Workup

  1. extractionextracted with ether
  2. washthe extracts washed with saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. customevaporated

Sources & evidence

ORD record
ord-2520815ded904ac4a3a5b4148ce88e17
Source dataset
uspto-grants-1977_02
Patent number
US04006144

Reaction notes

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