HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 435675Generated: October 29, 2026
Thiophenol → 5-Nitro-2-(phenylsulfanyl)benzaldehyde
https://huagongshe.com/reaction/435675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | 2-Chloro-5-nitrobenzaldehyde | HCID 72933 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-Nitro-2-(phenylsulfanyl)benzaldehyde | HCID 2981067 | — |
Reaction Steps
A solution of 480 g of 2-chloro-5-nitro-benzaldehyde in 3.2 litres of ethanol is treated dropwise under a nitrogen atmosphere at 30°-40° C with stirring within 4 hours with a solution of 320 g of thiophenol in 120 g of sodium hydroxide, 2 litres of ethanol and 440 ml of water. The mixture is stirred for a further 30 minutes at 60° C, then cooled to 0° C and filtered. There is obtained crude crystalline 3-nitro-6-(phenylthio)-benzaldehyde of melting point 96°-100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04006144 |
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| Source dataset | uspto-grants-1977_02 |
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| ORD ID | ord-ad1254f66beb4a5c958b8997928ffbfd |
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| Source note | uspto-grants-1977_02 |
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