Potassium Iodide → HCID 21481149, compound

Participants

Reaction Steps

5.9 g of 1-(10,11-dihydro-2-iodo-dibenzo[b,f]thiepin-10-yl)-piperazine are treated, together with 3.3 g of powdered potassium carbonate, 0.07 g of potassium iodide and 40 ml of toluene, with 4.35 g of N-(β-chloroethyl)-oxazolidinone and the mixture is heated under reflux for 27 hours. The mixture is then poured on to water and diluted with chloroform. The organic phase is extracted with 2-N hydrochloric acid. The aqueous phase is made alkaline with sodium hydroxide and extracted with chloroform. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The residue is chromatographed over aluminium oxide. There is obtained 3-[ 2-[4-(10,11-dihydro-2-iodo-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl ]-2-oxazolidinone which is converted into the maleate by treatment with maleic acid. The maleate melts at 176°-177° C.

Provenance & Evidence