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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43573Generated: October 28, 2026

Methanol → HCID 60135868, compound

https://huagongshe.com/reaction/43573

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl 2-[4-[[(5-chloro-4-ethyl-1H-imidazol-2-yl)carbonyl]amino]phenyl]-4-oxazolecarboxylateHCID 67549191—
SolventTetrahydrofuranHCID 8028—
ProductHCID 60135868HCID 6013586848.5%

Reaction Steps

The same operation as in Example (91d) was performed using methyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-1,3-oxazole-4-carboxylate obtained in Example (96c) (0.12 g, 0.32 mmol), 2 N lithium hydroxide (2 mL, 4 mmol), methanol (3 mL) and tetrahydrofuran (5 mL), to obtain 56 mg of the title compound as a light brown solid (48%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-fa43c6800a824ebaa7679d3944a9d2fa
Source noteuspto-grants-2013_09