Diethyl Ether → HCID 178446997, compound

Participants

Reaction Steps

To a cooled, stirred mixture of 3 g. of 1,2,4-triazole-3-carboxamide and 3.4 g. of pivaloyl chloride in 125 ml. of anhydrous diethyl ether is added rapidly 2.75 g. of triethylamine. The cooling bath is removed and the mixture is stirred at room temperature for 24 hours. The off-white solid is collected by filtration and washed thoroughly with diethyl ether and then cold water. The ether-cold water filtrate deposits another solid almost immediately. This solid is collected by filtration and dried in vacuo for 3.5 hours, yielding 0.22 g. This 0.22 g. is extracted with hot, dry acetonitrile. Concentration of the acetonitrile filtrate to a very small volume gives a colorless, crystalline solid which is collected, washed with a small amount of acetonitrile and dried in vacuo for 2 hours, yielding 50 mg., m.p. 132°-140° C. (dec.).

Provenance & Evidence