Methyl 5-methyl-2-(4-nitrophenyl)oxazole-4-carboxylate → Methyl 2-(4-aminophenyl)-5-methyl-1,3-oxazole-4-carboxylate

Participants

Reaction Steps

The same operation as in Example (95b) was performed using methyl 5-methyl-2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate obtained in Example (97c) (0.75 g, 2.86 mmol), 10% Pd/C (0.3 g) and methanol (10 mL). Purification by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/2, 1/1, 1/2, 1/4) gave 0.44 g of the title compound as a colorless solid (66%).

Provenance & Evidence