Isopropylamine → HCID 21481344, compound

HRID 435770Notes

Reaction equation

HRID 435770 reaction equation
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]2[CH:15]3[CH2:19][CH2:20][CH:8]([C:9]4[C:14]3=[CH:13][CH:12]=[CH:11][CH:10]=4)[C:7]=2[CH:6]=1.[CH:22]([NH2:25])([CH3:24])[CH3:23]>>[OH:1][CH:2]([CH2:21][NH:25][CH:22]([CH3:24])[CH3:23])[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]2[CH:15]3[CH2:19][CH2:20][CH:8]([C:9]4[C:14]3=[CH:13][CH:12]=[CH:11][CH:10]=4)[C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 21481347HCID 21481347, compound

Product 1

HCID 21481344HCID 21481344, compound

Procedure

40.95 g of 2-[2,3-epoxy-propoxy]-9,10-dihydro-9,10-ethano-anthracene and 48 ml of isopropylamine are dissolved in 700 ml of absolute alcohol and the solution is boiled for 20 hours under reflux. The reaction mixture is then evaporated to dryness and the residue is recrystallised from 180 ml of toluene. 2-[2-Hydroxy-3-isopropylamino-propoxy]-9,10-dihydro-9,10-ethano-anthracene thus obtained, melts at 126°-127° C.

Workup

  1. temperatureunder reflux
  2. customThe reaction mixture is then evaporated to dryness
  3. customthe residue is recrystallised from 180 ml of toluene

Sources & evidence

ORD record
ord-ca10a987420f45938ef2a7b433085a44
Source dataset
uspto-grants-1977_02
Patent number
US04006184

Reaction notes

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