Hydrochloric Acid → HCID 21481316, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4'-chloro-5'-methyl-6'-hydroxyspiro(cyclopentane-1,2'-indan)-1',3'-dione (4.0 g., 0.015 mole) in tetrahydrofuran (100 ml.) is cooled to 15° C. and treated over 5 minutes with a solution of sodium bis-(2-methoxyethoxy)aluminum hydride (10 ml. of a 70% solution in benzene). The reaction is stirred one-half hour at 25° C., cooled to 10° C. and slowly treated with 20% aqueous hydrochloric acid until acidic. The organic phase is evaporated to an oil, dissolved in ether, washed with water, dried over magnesium sulfate and the solvent evaporated affording 4'-chloro-5'-methylspiro(cyclopentane-1,2'-indan)-1',3',6'-triol.

Provenance & Evidence