Thionyl Chloride → Methyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-5-methyl-1,3-oxazole-4-carboxylate

Participants

Reaction Steps

The same operation as in Example (91c) was performed using 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid (0.17 g, 1 mmol), thionyl chloride (5 mL), methyl 2-(4-aminophenyl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (97d) (0.15 g, 0.65 mmol) and pyridine (5 mL), to obtain 0.14 g of the title compound as a light pink solid (56%).

Provenance & Evidence