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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43579Generated: October 29, 2026

Methanol → HCID 59615400, compound

https://huagongshe.com/reaction/43579

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-5-methyl-1,3-oxazole-4-carboxylateHCID 67549422—
SolventTetrahydrofuranHCID 8028—
ProductHCID 59615400HCID 5961540079.3%

Reaction Steps

The same operation as in Example (91d) was performed using methyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (97e) (0.14 g, 0.36 mmol), 2 N lithium hydroxide (2 mL, 4 mmol), methanol (3 mL) and tetrahydrofuran (5 mL), to obtain 107 mg of the title compound as a light pink solid (79%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-c2b9a6b0a18e4755b480865c7a3d0197
Source noteuspto-grants-2013_09