反应详情

2-(1-Cyclohexenyl)cyclohexanone (17.8 g., 0.1 mole), hexanamide (11.5 g., 0.1 mole), 5.0 g. of a highly acidic resin, Amberlyst 15, and toluene (150 ml) are mixed, stirred and heated at reflux for 16 hours. The water formed in the course of the reaction is azeotroped from the reaction mixture. The hot solution is decanted from the Amberlyst catalyst, the catalyst washed with toluene (200 ml.), and the toluene fractions are combined. Pentane (300 ml.) is added to the toluene solution, the mixture chilled in ice and filtered to remove 3.65 g. of unreacted hexanamide. The orange filtrate is stripped to yield 24 g. of crude product, an oil.

1. temperatureheated
2. temperatureat reflux for 16 hours
3. customis azeotroped from the reaction mixture
4. customThe hot solution is decanted from the Amberlyst catalyst
5. washthe catalyst washed with toluene (200 ml.)
6. additionPentane (300 ml.) is added to the toluene solution
7. temperaturethe mixture chilled in ice
8. filtrationfiltered
9. customto remove 3.65 g
10. customto yield 24 g