反应详情

One gram of 5-nitrothiazole-2-carboxylic acid chloride in 10 ml. of methylene chloride is combined with 850 mg. of 2,3,5-trimethylanisole and then with 1.6 g. of aluminum chloride. After three hours of agitation at room temperature, the reaction mixture is poured on 50 ml. of 1N HCl and extracted with ethyl acetate. After drying of the solution and evaporating the solvent under vacuum, the crystalline residue is recrystallized from methanol/chloroform.

1. additionthe reaction mixture is poured on 50 ml
2. extractionof 1N HCl and extracted with ethyl acetate
3. customAfter drying of the solution
4. customevaporating the solvent under vacuum
5. customthe crystalline residue is recrystallized from methanol/chloroform