Ethyl chloroformate → HCID 21481577, compound

HRID 435817Notes

Reaction equation

HRID 435817 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[C:16]([O:18][CH2:19][CH3:20])=[O:17]>N1C=CC=CC=1>[CH2:19]([O:18][C:16](=[O:17])[NH:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1)[CH3:20]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 843966-Propoxybenzothiazol-2-amine

Product 1

HCID 21481577HCID 21481577, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a chilled solution of 10.4 g. 2-amino-6-n-propoxybenzothiazole in 50 ml dry pyridine is dropwise added 6 g. ethyl chloroformate with stirring. The mixture is then allowed to stand at room temperature for 8 hrs. It is poured in 200 g. of ice water and stirred for 30 mins. The white solid product is separated by filtration and dried. Crystallization from ethanol gave 12 g. of the product. m.p. 175°-177° C.

Workup

  1. additionIt is poured in 200 g
  2. customThe white solid product is separated by filtration
  3. customdried
  4. customCrystallization from ethanol
  5. customgave 12 g

Sources & evidence

ORD record
ord-36c3c730e30f40c3abeb69f306b3865f
Source dataset
uspto-grants-1977_02
Patent number
US04006242

Reaction notes

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