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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43585Generated: October 28, 2026

Methanol → HCID 59615459, compound

https://huagongshe.com/reaction/43585

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantEthyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-5-ethyl-1,3-oxazole-4-carboxylateHCID 67548256—
SolventTetrahydrofuranHCID 8028—
ProductHCID 59615459HCID 5961545987%

Reaction Steps

The same operation as in Example (91d) was performed using ethyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}phenyl)-5-ethyl-1,3-oxazole-4-carboxylate obtained in Example (99c) (0.12 g, 2.88 mmol), 2 N lithium hydroxide (2 mL, 4 mmol), methanol (2 mL) and tetrahydrofuran (5 mL), to obtain 97 mg of the title compound as a light pink solid (87%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-47c37a86afec48b4b740271b8f3b501b
Source noteuspto-grants-2013_09