Imidazole → HCID 131710636, compound

Participants

Reaction Steps

2.72 g. of imidazole in 50 ml. of dimethylformamide is combined with 1.2 g. of sodium hydride suspension (80% strength). After allowing the mixture to stand at room temperature for 1.5 hours, 12.7 g. of (2-chloromethylphenyl)-(2,4-dichlorobenzyl)-sulfide is added thereto (prepared analogously to J. Org. Chem. 30 [1965] 4074), and the mixture is agitated for 20 hours at room temperature. After working up the mixture as indicated in Example 2, 12.5 g. of (2,4-dichlorobenzyl)-[2-(1-imidazolylmethyl)-phenyl]-sulfide, hydrochloride, is obtained by recrystallization from methylene chloride, m.p. 171°-175°.

Provenance & Evidence